Fantastic achievement Bob 
Any idea if the Covid benefits are permanent or is there not enough known yet.
Dunno Stu, sorry.
1 Like
From Claude AI
is there evidence that mounjaro has permanent benefits for long covid?
Synthesizing trial data and anecdotal evidence on tirzepatide
Synthesizing trial data and anecdotal evidence on tirzepatide
I’ll look into the current research on this.
Weighed anecdotal evidence against lack of permanent benefit proof
Weighed anecdotal evidence against lack of permanent benefit proof
Short answer: no. There’s no evidence of permanent benefit, and frankly no high-quality evidence of benefit at all yet — just promising early signals.
Here’s where things actually stand. There’s currently no proven treatment for long COVID, and tirzepatide is being investigated rather than established. The enthusiasm comes mostly from anecdotal data: one doctor’s survey of long COVID patients who’d tried the drug showed 60% to 90% saw improvement. That’s striking, but a physician’s informal survey of their own patients is the weakest tier of evidence — no control group, no blinding, prone to selection and placebo effects. Medical XpressKPBS
The rigorous test is just getting underway. Scripps Research has launched a randomized, placebo-controlled trial (LoCITT-T) that will monitor 1,000 participants over 12 months, assessing fatigue and other outcomes, with half receiving tirzepatide and half a placebo. The hypothesis is that it works by reducing inflammation, primarily neuroinflammation, with possible secondary benefits from improvements in weight, blood pressure, and blood sugar. As of late 2025 they were only about a quarter of the way through recruitment, so results are still a way off. Medical Xpress + 2
On the “permanent” part specifically, two things are worth flagging. First, the trial only measures outcomes over 12 months — it isn’t designed to answer whether any benefit persists after stopping. Second, what we know about GLP-1/GIP drugs in their established uses points the other way: the weight-loss data show benefits are maintained while taking the drug (sustained weight loss for up to 3 years on continued once-weekly dosing), and weight typically returns after discontinuation. There’s no mechanistic reason yet to expect a durable “cure” effect for long COVID that outlasts treatment, though that’s genuinely unknown until the data come in. aol
So if you’re weighing this for yourself or someone else: it’s a legitimate, serious line of research with real hope behind it, but it’s still experimental for long COVID, and claims of permanent benefit aren’t supported. Worth discussing with a doctor rather than acting on the anecdotal numbers.
This touches on health decisions that are pretty individual — I’m not a doctor, and if you’re considering it for a specific situation, a clinician who knows the full picture would be the right person to talk it through with.
2 Likes
Made the switch to Wegovy 1mg from Monjaro 10 mg.
Been easy so far and the weight loss continues, half the price. Will use this for a few months before pulling the plug.
3 Likes