Full breakdown and flounce in front of as many staff as possible.
Prepare a long rambling and very personal leaving speech and cry your way through most of it. Make it as awkward as possible for anyone that has to witness it.
(Maybe back this up with a formal letter of resignation to your line manager).
Many moons ago I phoned HR and asked how I should resign. I was asked why I wanted to quit and when the HR person realised that it was partly related to stress, he suggested that I might be better advised to go off sick. It turned out to be very good advice. I was very lucky that a good person rather than a company man answered the phone.
Thatās extremely rare indeed! The actual job of HR is mostly about minimising corporate liability, not actually doing anything for the rank and file.
However if you want a reference etc then its best to be cordial, thank them for the opportunities or development etc that they have given you etc. A brief idea of why youāre leaving, which can be as vague or specific as you like.
Or you could just say youāre leaving because of Brexit and keep them guessing!